Short term optical defocus perturbs normal developmental shifts in retina/RPE protein abundance.

ABSTRACT:

Background

Myopia (short-sightedness) affects approximately 1.4 billion people worldwide, and prevalence is increasing. Animal models induced by defocusing lenses show striking similarity with human myopia in terms of morphology and the implicated genetic pathways. Less is known about proteome changes in animals. Thus, the present study aimed to improve understanding of protein pathway responses to lens defocus, with an emphasis on relating expression changes to no lens control development and identifying bidirectional and/or distinct pathways across myopia and hyperopia (long-sightedness) models.

Results

Quantitative label-free proteomics and gene set enrichment analysis (GSEA) were used to examine protein pathway expression in the retina/RPE of chicks following 6 h and 48 

SUBMITTER: Riddell N 

PROVIDER: S-EPMC6116556 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature