The mitochondrial pathway is involved in sodium fluoride (NaF)-induced renal apoptosis in mice.

ABSTRACT: The objective of the present study was to explore the molecular mechanism of apoptosis induced by sodium fluoride (NaF) in the mouse kidney by using the methods of flow cytometry, quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, and experimental pathology. 240 four-week-old ICR mice were randomly divided into 4 groups and exposed to different concentrations of NaF (0 mg kg^-1, 12 mg kg^-1, 24 mg kg^-1 and 48 mg kg^-1) for a period of 42 days. The results demonstrated that NaF increased cell apoptosis and the depolarization of the mitochondrial membrane potential (MMP), and that the mitochondrial pathway was involved in NaF-induced apoptosis. Alteration of the mitochondrial pathway was characterized by significantly increa

SUBMITTER: Wei Q 

PROVIDER: S-EPMC6116726 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature