Clinicopathological parameters influencing inhibitor development in patients with hemophilia A receiving on-demand therapy.

ABSTRACT:

Background

Development of inhibitors to transfused factor VIII in patients with hemophilia A continues to be a challenge for professionals involved in hemophilia care. The majority of patients in India receive 'on-demand' rather than prophylactic therapy. The present study was done to assess the prevalence of factor VIII inhibitors in patients with hemophilia A (PWHA) receiving 'on-demand' therapy in a North Indian population and to study the clinicopathological parameters influencing the development of inhibitors.

Methods

The study group comprised of 300 PWHA. Detailed clinical parameters, treatment history, bleeding profile including family history were recorded. Diagnosis of hemophilia A was confirmed by relevant coagulation tests. Inhibitors were screened using mixing ba

SUBMITTER: Arshad S 

PROVIDER: S-EPMC6116755 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature