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Spontaneous Proliferation of CD4⁺ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naive CD8⁺ T Cells.

ABSTRACT: The fast and intense proliferative responses have been well documented for naïve T cells adoptively transferred into chronic lymphopenic hosts. This response known as spontaneous proliferation (SP), unlike antigen-independent lymphopenia-induced proliferation (LIP), is driven in a manner dependent on antigens derived from commensal microbiota. However, the precise nature of the SP response and its impact on homeostasis and function for T cells rapidly responding under this lymphopenic condition are still unclear. Here we demonstrate that, when naïve T cells were adoptively transferred into specific pathogen-free (SPF) but not germ-free (GF) RAG^-/- hosts, the SP response of these cells substantially affects the intensity and tempo of the responding T cells undergoing LIP. Therefo

SUBMITTER: Kim J

PROVIDER: S-EPMC6116856 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Spontaneous Proliferation of CD4⁺ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naive CD8⁺ T Cells.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Spontaneous Proliferation of CD4+ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naive CD8+ T Cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Spontaneous Proliferation of CD4⁺ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naive CD8⁺ T Cells.