A genome-wide association study identifies three novel genetic markers for response to tamoxifen: A prospective multicenter study.

ABSTRACT:

Purpose

Although association studies of genetic variations with the clinical outcomes of breast cancer patients treated with tamoxifen have been reported, genetic factors which could determine individual response to tamoxifen are not fully clarified. We performed a genome-wide association study (GWAS) to identify novel genetic markers for response to tamoxifen.

Experimental design

We prospectively collected 347 blood samples from patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative, invasive breast cancer receiving preoperative tamoxifen monotherapy for 14 to 28 days. We used Ki-67 response in breast cancer tissues after preoperative short-term tamoxifen therapy as a surrogate marker for response to tamoxifen. We performed GWAS and ge

SUBMITTER: Onishi H 

PROVIDER: S-EPMC6116947 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature