Significance Testing for Allelic Heterogeneity.

ABSTRACT: It is useful to detect allelic heterogeneity (AH), i.e., the presence of multiple causal SNPs in a locus, which, for example, may guide the development of new methods for fine mapping and determine how to interpret an appearing epistasis. In contrast to Mendelian traits, the existence and extent of AH for complex traits had been largely unknown until Hormozdiari et al. proposed a Bayesian method, called causal variants identification in associated regions (CAVIAR), and uncovered widespread AH in complex traits. However, there are several limitations with CAVIAR. First, it assumes a maximum number of causal SNPs in a locus, typically up to six, to save computing time; this assumption, as will be shown, may influence the outcome. Second, its computational time can be too demand

SUBMITTER: Deng Y 

PROVIDER: S-EPMC6116971 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature