Somatostatin analogues for refractory diarrhoea in familial amyloid polyneuropathy.

ABSTRACT:

Introduction

Familial amyloid polyneuropathy (FAP) is a genetic disease leading to the production of a variant transthyretin (TTR) or a beta variant β2-microglobulin. FAP may be associated with refractory diarrhoea. In this study, we assessed the efficacy and tolerance of somatostatin analogues in refractory diarrhoea associated with FAP.

Methods

FAP patients from the French national referral center who received somatostatin analogues for a refractory diarrhoea were retrospectively studied. We assessed remission of diarrhoea, as defined by a stool consistence of five or less on the Bristol stool scale, assessed after three to six months of follow-up. Stool frequency and continence before and after three to six months of treatment were also compared by the means of Wilcoxon a

SUBMITTER: Collins M 

PROVIDER: S-EPMC6116977 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature