A 3D two-point method for whole-brain water content and relaxation time mapping: Comparison with gold standard methods.

ABSTRACT: Quantitative imaging of the human brain is of great interest in clinical research as it enables the identification of a range of MR biomarkers useful in diagnosis, treatment and prognosis of a wide spectrum of diseases. Here, a 3D two-point method for water content and relaxation time mapping is presented and compared to established gold standard methods. The method determines free water content, H2O, and the longitudinal relaxation time, T1, quantitatively from a two-point fit to the signal equation including corrections of the transmit and receive fields. In addition, the effective transverse relaxation time, T2*, is obtained from an exponential fit to the multi-echo signal train and its influence on H2O values is corrected. The phantom results obtained with the proposed method show good

SUBMITTER: Schall M 

PROVIDER: S-EPMC6116981 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature