A proteomic signature that reflects pancreatic beta-cell function.

ABSTRACT:

Aim

Proteomics has the potential to enhance early identification of beta-cell dysfunction, in conjunction with monitoring the various stages of type 2 diabetes onset. The most routine method of assessing pancreatic beta-cell function is an oral glucose tolerance test, however this method is time consuming and carries a participant burden. The objectives of this research were to identify protein signatures and pathways related to pancreatic beta-cell function in fasting blood samples.

Methods

Beta-cell function measures were calculated for MECHE study participants who completed an oral glucose tolerance test and had proteomic data (n = 100). Information on 1,129 protein levels was obtained using the SOMAscan assay. Receiver operating characteristic curves were used to assess

SUBMITTER: Curran AM 

PROVIDER: S-EPMC6117012 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature