Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss.

ABSTRACT:

Background

Cisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss. This trial compared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects without jeopardizing overall and event-free survival.

Methods

We randomly assigned children older than 1 month and younger than 18 years of age who had standard-risk hepatoblastoma (≤3 involved liver sectors, no metastatic disease, and an alpha-fetoprotein level of >100 ng per milliliter) to receive cisplatin alone (at a dose of 80 mg per square meter of body-surface area, administered over a period of 6 hours) or cisplatin plu

SUBMITTER: Brock PR 

PROVIDER: S-EPMC6117111 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature