Predictions of novel Schistosoma mansoni - human protein interactions consistent with experimental data.

ABSTRACT: Infection by the human blood fluke, Schistosoma mansoni involves a variety of cross-species protein- protein interactions. The pathogen expresses a diverse arsenal of proteins that facilitate the breach of physical and biochemical barriers present in skin evasion of the immune system, and digestion of human plasma proteins including albumin and hemoglobin, allowing schistosomes to reside in the host for years. However, only a small number of specific interactions between S. mansoni and human proteins have been identified. We present and apply a protocol that generates testable predictions of S. mansoni-human protein interactions. In this study, we have preliminary predictions of novel interactions between schistosome and human proteins relevant to infection and the ability of the parasite

SUBMITTER: White Bear J 

PROVIDER: S-EPMC6117258 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature