CD59 is a potential biomarker of esophageal squamous cell carcinoma radioresistance by affecting DNA repair.

ABSTRACT: Radiation therapy is an important treatment modality for esophageal cancer. However, acquisition of radioresistance ultimately results in esophageal cancer relapse. CD59, a membrane-bound complement regulatory protein, can transduce signals via a Src kinase in the lipid raft, thus playing a complement-independent role. However, the effect of CD59 on the esophageal cancer response to ionizing radiation remains unclear. In this study, we found that the expression level of CD59 was positively correlated with the radioresistance of esophageal cancer cell lines and clinical specimens. High CD59 expression indicated poor overall survival (OS) and disease-free survival (DFS) in esophageal squamous cell carcinoma (ESCC) patients who received radiotherapy. Genetic alteration of CD59 expression modu

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC6117325 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature