The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease.

ABSTRACT: Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune response in a very complex and flowery manner. The history of host-parasite co-evolution has provided this protozoan with means of resisting, escaping or subverting the mechanisms of immunity and establishing a chronic infection. Despite many decades of research on the subject, the infection remains incurable, and the factors that steer chronic Chagas disease from an asymptomatic state to clinical onset are still unclear. As the relationship between T. cruzi and the host immune system is intricate, so is the amount and diversity of scientific knowledge on the matter. Many of the mechanisms of immunity are fairly well understood, but unveiling the factors that lead each of these to suc

SUBMITTER: Acevedo GR 

PROVIDER: S-EPMC6117404 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature