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New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164.

ABSTRACT: Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey's method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 ?M, respectively.

SUBMITTER: Fan Y 

PROVIDER: S-EPMC6117703 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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New Ansamycins from the Deep-Sea-Derived Bacterium <i>Ochrobactrum</i> sp. OUCMDZ-2164.

Fan Yaqin Y   Wang Cong C   Wang Liping L   Chairoungdua Arthit A   Piyachaturawat Pawinee P   Fu Peng P   Zhu Weiming W  

Marine drugs 20180815 8

Two new ansamycins, trienomycins H (<b>1</b>) and I (<b>2</b>), together with the known trienomycinol (<b>3</b>), were isolated from the fermentation broth of the deep-sea-derived bacterium <i>Ochrobactrum</i> sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey's method. Compound <b>1</b> exhibited cytotoxic effects on A549 and K562 cell lines with IC<sub>50</sub> values of 15 and 23 μM, respectively  ...[more]

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