Structure of an extended β₃ integrin.

ABSTRACT: Cells use adhesion receptor integrins to communicate with their surroundings. Integrin activation and cellular signaling are coupled with change from bent to extended conformation. β₃ integrins, including α_IIbβ₃, which is essential for the function of platelets in hemostasis and thrombosis, and α_Vβ₃, which plays multiple roles in diverse cell types, have been prototypes in understanding integrin structure and function. Despite extensive structural studies, a high-resolution integrin structure in an extended conformation remains to be determined. The human β₃ Leu33Pro polymorphism, located at the PSI domain, defines human platelet-specific alloantigens 1a and 1b (HPA-1a/b), immune response to which is a cause of posttransfusi

SUBMITTER: Zhou D 

PROVIDER: S-EPMC6117741 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature