Temporal instability of the post-surgical maxillary sinus microbiota.

ABSTRACT:

Background

Chronic rhinosinusitis is an inflammatory disorder in which the role of bacteria remains uncertain. While sinus outflow obstruction is often an initiating event, mucosal inflammation and dysbiosis may persist or develop in sinuses with widely patent surgical openings. Understanding of the relationship between dysbiosis and chronic sinus inflammation is obfuscated by inter-individual microbiota variability and likely intra-individual temporal variation that has yet to be defined. In this study, long-term microbiota stability is investigated within surgically-opened maxillary sinuses of individuals with and without sinus inflammatory disease.

Methods

Maxillary sinus swabs were performed in 35 subjects with longstanding maxillary antrostomies. Subjects with and witho

SUBMITTER: Koutsourelakis I 

PROVIDER: S-EPMC6117940 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature