A systematic review of cognitive functioning in early treated adults with phenylketonuria.

ABSTRACT:

Background

Even though early dietary management of phenylketonuria (PKU) successfully prevents severe neurological impairments, deficits in cognitive functioning are still observed. These deficits are believed to be the result of elevated levels of phenylalanine throughout life. Research on cognitive functioning in adults with PKU (AwPKU) often focuses on domains shown to be compromised in children with PKU, such as attention and executive functions, whereas other cognitive domains have received less attention. This systematic review aimed to provide an overview of cognitive functioning across domains examined in early treated (ET) AwPKU.

Methods

A systematic search was performed in Ovid MEDLINE(R), PsycINFO, Web of Science, Cochrane, Scopus, Embase, ScienceDirect, and PubMe

SUBMITTER: Hofman DL 

PROVIDER: S-EPMC6117942 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature