Paternal malnutrition programs breast cancer risk and tumor metabolism in offspring.

ABSTRACT:

Background

While many studies have shown that maternal factors in pregnancy affect the cancer risk for offspring, few studies have investigated the impact of paternal exposures on their progeny's risk of this disease. Population studies generally show a U-shaped association between birthweight and breast cancer risk, with both high and low birthweight increasing the risk compared with average birthweight. Here, we investigated whether paternal malnutrition would modulate the birthweight and later breast cancer risk of daughters.

Methods

Male mice were fed AIN93G-based diets containing either 17.7% (control) or 8.9% (low-protein (LP)) energy from protein from 3 to 10 weeks of age. Males on either group were mated to females raised on a control diet. Female offspring from cont

SUBMITTER: da Cruz RS 

PROVIDER: S-EPMC6117960 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature