Clinical significance of radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: a retrospective cohort study.

ABSTRACT:

Background

Radiological pleuroparenchymal fibroelastosis (PPFE) lesion is characterized by pleural thickening with associated signs of subpleural fibrosis on high-resolution computed tomography (HRCT). This study evaluated the clinical significance of radiological PPFE as an isolated finding or associated with other interstitial lung diseases (ILDs) in patients having fibrotic ILDs and registered for cadaveric lung transplantation (LT).

Methods

This retrospective study included 118 fibrotic ILD patients registered for LT. Radiological PPFE on HRCT was assessed. The impact of radiological PPFE on clinical features and transplantation-censored survival were evaluated.

Results

Radiological PPFE was observed in 30/118 cases (25%): definite PPFE (PPFE concentrated in the u

SUBMITTER: Tanizawa K 

PROVIDER: S-EPMC6117972 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature