The Postinjury Inflammatory State and the Bone Marrow Response to Anemia.

ABSTRACT: RATIONALE:The pathophysiology of persistent injury-associated anemia is incompletely understood, and human data are sparse. OBJECTIVES:To characterize persistent injury-associated anemia among critically ill trauma patients with the hypothesis that severe trauma would be associated with neuroendocrine activation, erythropoietin dysfunction, iron dysregulation, and decreased erythropoiesis. METHODS:A translational prospective observational cohort study comparing severely injured, blunt trauma patients who had operative fixation of a hip or femur fracture (n = 17) with elective hip repair patients (n = 22). Bone marrow and plasma obtained at the index operation were assessed for circulating catecholamines, systemic inflammation, erythropoietin, iron trafficking pathways, and erythroid progen

SUBMITTER: Loftus TJ 

PROVIDER: S-EPMC6118010 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature