Staphylococcus aureus Induces a Mucosal Type 2 Immune Response via Epithelial Cell-derived Cytokines.

ABSTRACT:

Rationale

Chronic rhinosinusitis with nasal polyps is characterized by a T-helper cell type 2-skewed upper airway inflammation. Mucosal Staphylococcus aureus colonization is found in the majority of patients with nasal polyps. S. aureus is known to induce type 2 cytokine release via enterotoxins.

Objectives

To investigate the impact of non-enterotoxin-producing S. aureus on type 2 cytokine release.

Methods

TSLP (thymic stromal lymphopoietin), IL-33, and type 2 cytokines were assessed in a human mucosal tissue model upon S. aureus infection.

Measurements and main results

S. aureus exposure increased the expression of IL-33, TSLP, IL-5, and IL-13 in nasal polyp tissue, accompanied by elevated expression levels of TSLP and IL-33 receptors, predominantly on CD3

SUBMITTER: Lan F 

PROVIDER: S-EPMC6118025 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature