IRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress.

ABSTRACT: Particulate matter (PM2.5) is a risk factor for organ injury and disease progression, such as lung, brain and liver. However, its effects on renal injury and the underlying molecular mechanism have not been understood. The inactive rhomboid protein 2 (iRhom2), also known as rhomboid family member 2 (Rhbdf2), is a necessary modulator for shedding of tumor necrosis factor-α (TNF-α) in immune cells, and has been explored in the pathogenesis of chronic renal diseases. In the present study, we found that compared to the wild type (iRhom2^+/+) mice, iRhom2 knockout (iRhom2^-/-) protected PM_2.5-exposed mice from developing severe renal injury, accompanied with improved renal pathological changes and functions. iRhom2^-/- mice exhibited reduced inflammatory

SUBMITTER: Chenxu G 

PROVIDER: S-EPMC6118040 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature