Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus.

ABSTRACT: Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants^1-4. However, how adult-born neurons regulate dentate gyrus information processing to protect from stress-induced anxiety-like behaviour is unknown. Here we show in mice that neurogenesis confers resilience to chronic stress by inhibiting the activity of mature granule cells in the ventral dentate gyrus (vDG), a subregion that is implicated in mood regulation. We found that chemogenetic inhibition of adult-born neurons in the vDG promotes susceptibility to social defeat stress, whereas increasing neurogenesis confers resilience to chronic stress. By using in vivo calcium imaging to record neu

SUBMITTER: Anacker C 

PROVIDER: S-EPMC6118212 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature