Differences in clinical characteristics and mutational pattern between synchronous and metachronous colorectal liver metastases.

ABSTRACT:

Purpose

To investigate differences in clinical characteristics and mutational patterns between synchronous and metachronous colorectal liver metastases (CLMs).

Patients and methods

From June 2008 to December 2014, patients with RAS wild-type CLMs treated at Zhongshan Hospital, Fudan University were included. DNA extracted from formalin-fixed paraffin-embedded tissue of primary tumors was sequenced with next-generation sequencing for single-nucleotide polymorphism of 96 genes according to custom panel. Mutations were compared between synchronous and metachronous liver metastases and correlated with clinical characteristics.

Results

A total of 161 patients were included: 93 patients with synchronous CLM and 68 patients with metachronous CLM. Patients with metachronous C

SUBMITTER: Zheng P 

PROVIDER: S-EPMC6118248 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature