Widespread evolutionary crosstalk among protein domains in the context of multi-domain proteins.

ABSTRACT: Domains are distinct units within proteins that typically can fold independently into recognizable three-dimensional structures to facilitate their functions. The structural and functional independence of protein domains is reflected by their apparent modularity in the context of multi-domain proteins. In this work, we examined the coupling of evolution of domain sequences co-occurring within multi-domain proteins to see if it proceeds independently, or in a coordinated manner. We used continuous information theory measures to assess the extent of correlated mutations among domains in multi-domain proteins from organisms across the tree of life. In all multi-domain architectures we examined, domains co-occurring within protein sequences had to some degree undergone concerted evolution. Thi

SUBMITTER: Jakubec D 

PROVIDER: S-EPMC6118372 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature