In silico drug absorption tract: An agent-based biomimetic model for human oral drug absorption.

ABSTRACT:

Background

An agent-based modeling approach has been suggested as an alternative to traditional, equation-based modeling methods for describing oral drug absorption. It enables researchers to gain a better understanding of the pharmacokinetic (PK) mechanisms of a drug. This project demonstrates that a biomimetic agent-based model can adequately describe the absorption and disposition kinetics both of midazolam and clonazepam.

Methods

An agent-based biomimetic model, in silico drug absorption tract (ISDAT), was built to mimic oral drug absorption in humans. The model consisted of distinct spaces, membranes, and metabolic enzymes, and it was altogether representative of human physiology relating to oral drug absorption. Simulated experiments were run with the model, and the re

SUBMITTER: Deng J 

PROVIDER: S-EPMC6118387 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature