High-accuracy determination of internal circadian time from a single blood sample.

ABSTRACT:

Background

The circadian clock is a fundamental and pervasive biological program that coordinates 24-hour rhythms in physiology, metabolism, and behavior, and it is essential to health. Whereas therapy adapted to time of day is increasingly reported to be highly successful, it needs to be personalized, since internal circadian time is different for each individual. In addition, internal time is not a stable trait, but is influenced by many factors, including genetic predisposition, age, sex, environmental light levels, and season. An easy and convenient diagnostic tool is currently missing.

Methods

To establish a validated test, we followed a 3-stage biomarker development strategy: (a) using circadian transcriptomics of blood monocytes from 12 individuals in a constant routi

SUBMITTER: Wittenbrink N 

PROVIDER: S-EPMC6118629 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature