A Connectome-wide Functional Signature of Transdiagnostic Risk for Mental Illness.

ABSTRACT:

Background

High rates of comorbidity, shared risk, and overlapping therapeutic mechanisms have led psychopathology research toward transdiagnostic dimensional investigations of clustered symptoms. One influential framework accounts for these transdiagnostic phenomena through a single general factor, sometimes referred to as the p factor, associated with risk for all common forms of mental illness.

Methods

We build on previous research identifying unique structural neural correlates of the p factor by conducting a data-driven analysis of connectome-wide intrinsic functional connectivity (n = 605).

Results

We demonstrate that higher p factor scores and associated risk for common mental illness maps onto hyperconnectivity between visual association cortex and both fronto

SUBMITTER: Elliott ML 

PROVIDER: S-EPMC6119080 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature