Associations between chronotype, morbidity and mortality in the UK Biobank cohort.

ABSTRACT: Later chronotype (i.e. evening preference) and later timing of sleep have been associated with greater morbidity, including higher rates of metabolic dysfunction and cardiovascular disease (CVD). However, no one has examined whether chronotype is associated with mortality risk to date. Our objective was to test the hypothesis that being an evening type is associated with increased mortality in a large cohort study, the UK Biobank. Our analysis included 433 268 adults aged 38-73 at the time of enrolment and an average 6.5-year follow-up. The primary exposure was chronotype, as assessed through a single self-reported question-defining participants as definite morning types, moderate morning types, moderate evening types or definite evening types. The primary outcomes were all-cause mortality

SUBMITTER: Knutson KL 

PROVIDER: S-EPMC6119081 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature