Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks.

ABSTRACT:

Rationale

Alcohol-associated stimuli capture attention, yet drinkers differ in the precise stimuli that become paired with intoxication.

Objectives

Extending our prior work to examine the influence of alcoholism risk factors, we paired abstract visual stimuli with intravenous alcohol delivered covertly and examined brain responses to these Pavlovian-conditioned stimuli in fMRI when subjects were not intoxicated.

Methods

Sixty healthy drinkers performed task-irrelevant alcohol conditioning that presented geometric shapes as conditioned stimuli. Shapes were paired with a rapidly rising alcohol limb (conditioned stimulus; CS+) using intravenous alcohol infusion targeting a final peak breath alcohol concentration of 0.045 g/dL or saline (CS-) infusion at matched rates. On

SUBMITTER: Oberlin BG 

PROVIDER: S-EPMC6119082 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature