Quantification of tissue-engineered trachea performance with computational fluid dynamics.

ABSTRACT:

Objectives/hypothesis

Current techniques for airway characterization include endoscopic or radiographic measurements that produce static, two-dimensional descriptions. As pathology can be multilevel, irregularly shaped, and dynamic, minimal luminal area (MLA) may not provide the most comprehensive description or diagnostic metric. Our aim was to examine the utilization of computational fluid dynamics (CFD) for the purpose of defining airway stenosis using an ovine model of tissue-engineered tracheal graft (TETG) implantation.

Study design

Animal research model.

Methods

TETGs were implanted into sheep, and MLA was quantified with imaging and endoscopic measurements. Graft stenosis was managed with endoscopic dilation and stenting when indicated. Geometries of the TETG

SUBMITTER: Eichaker L 

PROVIDER: S-EPMC6119110 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature