Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy.

ABSTRACT: Severe thrombocytopenia (≤50×10⁹ platelets/L) due to hematological malignancy and intensive chemotherapy is associated with an increased risk of clinically significant bleeding. Since the bleeding risk is not linked to the platelet count only, other hemostatic factors must be involved. We studied platelet function in 77 patients with acute leukemia, multiple myeloma or malignant lymphoma, who experienced chemotherapy-induced thrombocytopenia. Platelets from all patients - independent of disease or treatment type - were to a variable extent compromised in Ca²⁺ flux, integrin a β activation and P-selectin expression when stimulated with a panel^IIbof³ agonists. The patients' platelets were also impaired in spreading on fibrinogen. Whereas the Ca

SUBMITTER: Baaten CCFMJ 

PROVIDER: S-EPMC6119160 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature