The therapeutic potential of bacteriophages targeting gram-negative bacteria using Galleria mellonella infection model.

ABSTRACT:

Background

Phage therapy is the therapeutic use of bacteriophages to treat highly drug resistant bacterial infections. The current surge in bacteriophage therapy is motivated mainly because of the emergence of antibiotic-resistant bacteria in clinics. This study evaluated the therapeutic potential of three bacteriophages isolated against Escherichia coli ec311, Klebsiella pneumoniae kp235 and Enterobacter cloacae el140 strains using Galleria mellonella. The in vitro activity of three different phages belonging to Podoviridae and Myoviridae families was studied by the double agar overlay method against multi-drug resistant strains. Larval survivability studies were performed to evaluate the potential of phages against infection using G. mellonella.

Results

All the three phage

SUBMITTER: Manohar P 

PROVIDER: S-EPMC6119258 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature