Prevalence and clinicopathological characteristics of mismatch repair-deficient colorectal carcinoma in early onset cases as compared with late-onset cases: a retrospective cross-sectional study in Northeastern Iran.

ABSTRACT:

Objectives

Lynch syndrome (LS), a genetically inherited autosomal disorder, increases the incidence of colorectal carcinoma (CRC). We aimed to perform a universal strategy to assess the prevalence and clinicopathological characteristics of early onset CRCs at high risk of LS versus late-onset ones in the Iranian population.

Setting

A local population-based study from Northeastern Iran.

Participants

321 consecutive CRCs and pathology specimen screened between 2013 and 2016.

Primary and secondary outcome measures

Retrospectively, information regarding the clinical criteria was obtained by interviewing the patients with CRC or, their families. Pathologists tested tumours with immunohistochemistry (IHC) staining of four mismatch repair (MMR) proteins (MLH1, MSH2

SUBMITTER: Goshayeshi L 

PROVIDER: S-EPMC6119423 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature