Perioperative urinary thromboxane metabolites and outcome of coronary artery bypass grafting: a nested case-control study.

ABSTRACT:

Objective

As a marker of in vivo thromboxane generation, high-level urinary thromboxane metabolites (TXA-M) increase the occurrence of cardiovascular events in high-risk patients. To investigate whether perioperative urinary TXA-M level is associated with major adverse cardiac and cerebrovascular events (MACCE) after coronary artery bypass graft (CABG) surgery, we designed a nested case-control study.

Design

Observational, nested case-control study.

Setting

Single-centre outcomes research in Fuwai Hospital, Beijing, China.

Participants

One thousand six hundred and seventy Chinese patients undergoing CABG surgery from September 2011 to October 2013.

Methods

We obtained urinary samples from 1670 Chinese patients undergoing CABG 1 hour before surgery (pre-C

SUBMITTER: Liu H 

PROVIDER: S-EPMC6119430 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature