Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.

ABSTRACT:

Objective

Previous gene expression analysis identified a network of coexpressed genes that is associated with β-amyloid neuropathology and cognitive decline in older adults. The current work targeted influential genes in this network with quantitative proteomics to identify potential novel therapeutic targets.

Methods

Data came from 834 community-based older persons who were followed annually, died, and underwent brain autopsy. Uniform structured postmortem evaluations assessed the burden of β-amyloid and other common age-related neuropathologies. Selected reaction monitoring quantified cortical protein abundance of 12 genes prioritized from a molecular network of aging human brain that is implicated in Alzheimer's dementia. Regression and linear mixed models examined the pr

SUBMITTER: Yu L 

PROVIDER: S-EPMC6119500 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature