Combined neuropathological pathways account for age-related risk of dementia.

ABSTRACT:

Objective

Our objectives were to characterize the inter-relation of known dementia-related neuropathologies in one comprehensive model and quantify the extent to which accumulation of neuropathologies accounts for the association between age and dementia.

Methods

We used data from 1,362 autopsied participants of three community-based clinicopathological cohorts: the Religious Orders Study, the Rush Memory and Aging Project, and the Minority Aging Research Study. We estimated a series of structural equation models summarizing a priori hypothesized neuropathological pathways between age and dementia risk individually and collectively.

Results

At time of death (mean age, 89 years), 44% of our sample had a clinical dementia diagnosis. When considered individually, our vas

SUBMITTER: Power MC 

PROVIDER: S-EPMC6119518 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature