Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia.

ABSTRACT: Schizophrenia is a devastating illness that affects over 2 million people in the United States and costs society billions of dollars annually. New insights into the pathophysiology of schizophrenia are needed to provide the conceptual framework to facilitate development of new treatment strategies. We examined bioenergetic pathways in the dorsolateral prefrontal cortex (DLPFC) of subjects with schizophrenia and control subjects using western blot analysis, quantitative real-time polymerase chain reaction, and enzyme/substrate assays. Laser-capture microdissection-quantitative polymerase chain reaction was used to examine these pathways at the cellular level. We found decreases in hexokinase (HXK) and phosphofructokinase (PFK) activity in the DLPFC, as well as decreased PFK1 mRNA expression

SUBMITTER: Sullivan CR 

PROVIDER: S-EPMC6119539 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature