Haplotype Analysis of PPARγ Gene Polymorphisms and the Lipoprotein (a) Level.

ABSTRACT:

Background

Lipoprotein (a) [Lp(a)], as an independent risk factor for cardiovascular disease, is more likely to be genetically determined according to the increasing evidence of epidemiologic and clinical studies in recent years. Peroxisome proliferator-activated receptor (PPAR) γ, the ligand-activated transcription factors, was considered as an indispensable role in the process of lipid metabolism. This study was designed to explore the associations of three single-nucleotide polymorphisms (SNPs) and the haplotypes of the peroxisome proliferator-activated receptor (PPAR)γ gene with the level of Lp(a).

Methods

Participants were recruited under the framework of the PMMJS (The Prevention of Metabolic Syndrome (MS) and Multi-metabolic Disorders in Jiangsu Province of China Stud

SUBMITTER: Shen C 

PROVIDER: S-EPMC6119570 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature