Prescription opioid use before and after kidney transplant: Implications for posttransplant outcomes.

ABSTRACT: Evolving literature suggests that the epidemic of prescription opioid use affects the transplant population. We examined a novel database wherein national U.S. transplant registry records were linked to a large pharmaceutical claims warehouse (2007-2015) to characterize prescription opioid use before and after kidney transplant, and associations (adjusted hazard ratio, _95%LCL aHR_95%UCL ) with death and graft loss. Among 75 430 eligible patients, 43.1% filled opioids in the year before transplant. Use was more common among recipients who were women, white, unemployed, publicly insured, and with longer pretransplant dialysis. Of those with the highest level of pretransplant opioid use, 60% continued high-level use posttransplant. Pretransplant opio

SUBMITTER: Lentine KL 

PROVIDER: S-EPMC6119653 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature