Basal-like breast cancer engages tumor-supportive macrophages via secreted factors induced by extracellular S100A4.

ABSTRACT: The tumor microenvironment (TME) may influence both cancer progression and therapeutic response. In breast cancer, particularly in the aggressive triple-negative/basal-like subgroup, patient outcome is strongly associated with the tumor's inflammatory profile. Tumor-associated macrophages (TAMs) are among the most abundant immune cells in the TME, shown to be linked to poor prognosis and therapeutic resistance. In this study, we investigated the effect of the metastasis- and inflammation-associated microenvironmental factor S100A4 on breast cancer cells (BCCs) of different subtypes and explored their further interactions with myeloid cells. We demonstrated that extracellular S100A4 activates BCCs, particularly the basal-like subtype, to elevate secretion of pro-inflammatory cytokines. The

SUBMITTER: Prasmickaite L 

PROVIDER: S-EPMC6120223 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature