Observation period for changes in proteinuria and risk prediction of end-stage renal disease in general population.

ABSTRACT:

Aim

Proteinuria is known to be an independent risk factor of end-stage renal disease (ESRD). But the associations between changes in dipstick proteinuria and the risk of ESRD in the general population and its appropriate observation period to predict incident ESRD are unknown.

Methods

We assessed the changes in dipstick proteinuria in 69 021 participants aged ≥20 years who participated in health check-ups from 1993 and more than once until 1996 in Okinawa, Japan. Development of ESRD until 2011 was identified using dialysis registry. Cox proportional hazards model and receiver operating characteristic (ROC) curve were used.

Results

At baseline, proteinuria (±) and ≥(1+) were observed in 2.4% and 1.2% of total subjects. 1.5% of subjects had decreased and 9.4% of subject

SUBMITTER: Usui T 

PROVIDER: S-EPMC6120455 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature