Simultaneous multislice acquisition without trajectory modification for hyperpolarized ¹³ C experiments.

ABSTRACT:

Purpose

To investigate the feasibility of performing large FOV hyperpolarized ¹³ C metabolic imaging using simultaneous multislice excitation.

Methods

A spectral-spatial multislice excitation pulse was constructed by cosine modulation and incorporated into a ¹³ C spiral imaging sequence. Phantom and in vivo pig experiments were performed to test the feasibility of simultaneous multislice data acquisition and image reconstruction. In vivo cardiac-gated images of hyperpolarized pyruvate, bicarbonate, and lactate were obtained at 1 × 1 × 1 cm³ resolution over a 48 × 48 × 24 cm³ FOV with 2-fold acceleration in the slice direction. Sensitivity encoding was used for image reconstruction with both autocalibrated and numerically calculated

SUBMITTER: Lau AZ 

PROVIDER: S-EPMC6120460 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature