Emerging depression in adolescence coincides with accelerated frontal cortical thinning.

ABSTRACT: BACKGROUND:Adolescence is a transition period characterized by heightened emotional reactivity, which for some sets the stage for emerging depressive symptoms. Prior studies suggest that adolescent depression is associated with deviant cortical and subcortical brain structure. Longitudinal studies are, however, currently scarce, but critical to detect which adolescents are at risk for developing depressive symptoms. METHODS:In this longitudinal study, a community sample of 205 participants underwent magnetic resonance imaging (MRI) in three biennial waves (522 scans) spanning 5 years across ages 8-25 years. Depressive symptomatology was assessed using self-report at the third time point. Mixed models were used to examine the relations between structural brain development, specifically regi

SUBMITTER: Bos MGN 

PROVIDER: S-EPMC6120477 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature