Callosal and subcortical white matter alterations in schizophrenia: A diffusion tensor imaging study at multiple levels.

ABSTRACT: Diffusion tensor imaging and its distinct capability to detect micro-structural changes in vivo allows the exploration of white matter (WM) abnormalities in patients who have been diagnosed with schizophrenia; however, the results regarding the anatomical positions and degree of abnormalities are inconsistent. In order to obtain more robust and stable findings, we conducted a multi-level analysis to investigate WM disruption in a relatively large sample size (142 schizophrenia patients and 163 healthy subjects). Specifically, we evaluated the univariate fractional anisotropy (FA) in voxel level; the bivariate pairwise structural connectivity between regions using deterministic tractography as the network node defined by the Human Brainnetome Atlas; and the multivariate network topol

SUBMITTER: Zhao W 

PROVIDER: S-EPMC6120601 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature