FDG PET Parkinson's disease-related pattern as a biomarker for clinical trials in early stage disease.

ABSTRACT:

Background

The development of therapeutic interventions for Parkinson disease (PD) is challenged by disease complexity and subjectivity of symptom evaluation. A Parkinson's Disease Related Pattern (PDRP) of glucose metabolism via fluorodeoxyglucose positron emission tomography (FDG-PET) has been reported to correlate with motor symptom scores and may aid the detection of disease-modifying therapeutic effects.

Objectives

We sought to independently evaluate the potential utility of the PDRP as a biomarker for clinical trials of early-stage PD.

Methods

Two machine learning approaches (Scaled Subprofile Model (SSM) and NPAIRS with Canonical Variates Analysis) were performed on FDG-PET scans from 17 healthy controls (HC) and 23 PD patients. The approaches were compared reg

SUBMITTER: Matthews DC 

PROVIDER: S-EPMC6120603 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature