Natural genetic variation in <i>C. elegans</i> identified genomic loci controlling metabolite levels.

ABSTRACT: Metabolic homeostasis is sustained by complex biological networks that respond to nutrient availability. Genetic and environmental factors may disrupt this equilibrium, leading to metabolic disorders, including obesity and type 2 diabetes. To identify the genetic factors controlling metabolism, we performed quantitative genetic analysis using a population of 199 recombinant inbred lines (RILs) in the nematode Caenorhabditis elegans We focused on the genomic regions that control metabolite levels by measuring fatty acid (FA) and amino acid (AA) composition in the RILs using targeted metabolomics. The genetically diverse RILs showed a large variation in their FA and AA levels with a heritability ranging from 32% to 82%. We detected strongly co-correlated metabolite clusters and 36 sig

SUBMITTER: Gao AW 

PROVIDER: S-EPMC6120624 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature