Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding.

ABSTRACT: Glucocorticoids are potent steroid hormones that regulate immunity and metabolism by activating the transcription factor (TF) activity of glucocorticoid receptor (GR). Previous models have proposed that DNA binding motifs and sites of chromatin accessibility predetermine GR binding and activity. However, there are vast excesses of both features relative to the number of GR binding sites. Thus, these features alone are unlikely to account for the specificity of GR binding and activity. To identify genomic and epigenetic contributions to GR binding specificity and the downstream changes resultant from GR binding, we performed hundreds of genome-wide measurements of TF binding, epigenetic state, and gene expression across a 12-h time course of glucocorticoid exposure. We found that glucocorti

SUBMITTER: McDowell IC 

PROVIDER: S-EPMC6120625 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature