Genetic variants related to urate and risk of Parkinson's disease.

ABSTRACT:

Introduction

Higher urate concentrations have been associated with a lower risk of developing Parkinson's disease (PD) and with slower rates of clinical decline in PD patients. Whether these associations reflect a neuroprotective effect of urate is unclear. Our objective was to assess whether genetic variants that modify circulating urate levels are also associated with altered PD risk.

Methods

Participants were from three large ongoing cohort studies: the Nurses' Health Study (NHS), the Health Professionals Follow-up Study (HPFS), and the Cancer Prevention Study II Nutrition Cohort (CPS-IIN). We examined associations between single nucleotide polymorphisms (SNPs) in SLC2A9 and other genes involved in urate transport and PD risk using conditional logistic regression among 14

SUBMITTER: Hughes KC 

PROVIDER: S-EPMC6120767 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature