Neisseria meningitidis disease-associated clones in Amazonas State, Brazil.

ABSTRACT:

Background

The aim of this study is to describe the molecular epidemiology of Neisseria meningitidis invasive disease before the introduction of serogroup C conjugate vaccine in Amazonas State in 2010.

Methods

Meningococcal disease reported cases were investigated in Amazonas State during the period 2000-2010. N. meningitidis isolates (n = 196) recovered from patients were genotyped by multilocus sequence typing (MLST) and sequencing of porB, porA, fetA, fHbp and penA. Antimicrobial susceptibility was determined using E-test.

Results

In the study period, 948 cases were reported; the incidence was 2.8 for the entire state and 4.8 per 100,000 in the capital of Manaus. Most meningococcal disease was caused by N. meningitidis belonging to ST-32 (72%; 141/196) or ST-103 (2

SUBMITTER: Silva LA 

PROVIDER: S-EPMC6120802 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature